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Effect of the administration of an antioxidant complex in patients with idiopathic astenoteratozoospermia

Ballescá, José Luis; Oliva, Rafael; Espinosa, Nadia; Corral, Juan Manuel. Rev Int Androl.2012; 10 :51-6 - vol.10 núm 02

Abstract

Introduction: The male factor is seen in almost 50% of the couples attending a reproductive clinic, and may be a result of a decrease in sperm count (oligozoospermia) or in sperm quality due to mobility defects (asthenozoospermia) or in its morphology (teratozoospermia). There are several studies that related the these sperm quality defects with the presence of sperm DNA fragmentation and suggest the possible beneficial effect of antioxidant treatments, although there is wide disparity in the results obtained.

Objectives: We have studied the effect of the administration of an antioxidant complex (Androferti® Laboratory Q Pharma) in patients with idiopathic asthenoteratozoospermia in order to contribute to the clarification of the possible beneficial effect of the empirical administration of antioxidants, in the present work.

Patients and methods: A total of 69 males in whom the antioxidant treatment was administered at a day dose of 1.5 g for 3 months were included. After completing the treatment, significant improvement was detected in sperm mobility (global mobility a+b improved from 22.04% to 28.95%; p = 0.001) and sperm morphology (the normal forms increased from 9.86 % to 14.78%, p <0.001). Discussion: Numerous publications have reported the beneficial effects of administering antioxidant substances on sperm DNA fragmentation. These effects could be translated into an improvement in semen and embryo quality, in case of pregnancy. Our study is in line with these finding, showing an improvement in most of the seminal parameters resulting from the administration of L-carnitine in association with other antioxidants, a treatment that appears to be particularly effective in younger patients.

Conclusions: Our results confirm the beneficial effect of the administration of an antioxidant complex in patients with idiopathic asthenoteratozoospermia, this improving their sperm quality, consequently favoring the desired pregnancy.

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×

Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA

Abad C, Amengual MJ, Gosálvez J, Coward K, Hannaoui N, Benet J, García-Peiró A, Prats J. Andrologia. 2012 Sep 3. doi: 10.1111/and.12003

Abstract

Abstract: The primary aim of this study was to determine the effect of oral antioxidant treatment (1500 mg of l-Carnitine; 60 mg of vitamin C; 20 mg of coenzyme Q10; 10 mg of vitamin E; 10 mg of zinc; 200 μg of vitamin B9; 50 μg of selenium; 1 μg of vitamin B12) during a time period of 3 months upon the dynamics of sperm DNA fragmentation following varying periods of sperm storage (0 h, 2 h, 6 h, 8 h and 24 h) at 37 °C in a cohort of 20 infertile patients diagnosed with asthenoteratozoospermia. A secondary objective was to use the sperm chromatin dispersion test (SCD) to study antioxidant effects upon a specific subpopulation of highly DNA degraded sperm (DDS). Semen parameters and pregnancy rate (PR) were also determined. Results showed a significant improvement of DNA integrity at all incubation points (P < 0.01). The proportion of DDS was also significantly reduced (P < 0.05). Semen analysis data showed a significant increase in concentration, motility, vitality and morphology parameters. Our results suggest that antioxidant treatment improves sperm quality not only in terms of key seminal parameters and basal DNA damage, but also helps to maintain DNA integrity. Prior administration of antioxidants could therefore promote better outcomes following assisted reproductive techniques.

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Evaluation of a antioxidant compound on seminal parameters of sperm concentration, mobility and morphology in patients with idiopatics oligoastenoteratozoospermia

Mateos Blanco, Jesús; Cabo Gonzalez, Juan Alonso Rev. Internacional Androl.2011; 09:109-15.

Abstract

Nowadays, the masculine factor is the person in charge of form isolated of 40 % of the cases of infertility of pair, sharing this protagonism of additional form in 20 % close to the feminine factor, for what of joint form, it represents 50 % of all the cases. In spite of the lack of scientific evidence, the empirical treatment has been in use widely and continues being done at present, basically to expense of compound of vitamins and other trace elements, which due to his antirust power, it would allow to improve seminal parameters as mobility or morphology.

Objetive: To study the changes in seminal parameters in a group of patients with idiophatic oligoastenoteratozoospermia, to whom they treatment was ruled by the antirust complex.

Material y métodos: 40 patients with idiophatic oligoastenoteratozoospermia were treated by the complex antirust Androferti (Laboratory Q Pharma).

Conclusions: The study demonstrated improvement of the seminal parameters concentration, progressive mobility and morphology to 3 and 6 months of treatment, presenting statistical significance the analysis of the information, which, given the improvement on the inventory of mobile sperms (REM), allows to these patients to come to technologies of assisted reproduction (TRA) as in vitro fertilization (FIV) or injection intracitoplasmática of sperms (ICSI) with major guarantee, or even, pairs who due to the initial REM necessarily had to resort to the above mentioned technology of reproduction, they can resort finally to artificial insemination (IAC) before the experienced improvement.

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×

Effect of a treatment with vitamins, L-carnitine and coenzyme Q10 on sperm head vacuolization and DNA fragmentation on in vitro fertilization patients

López Granollers, Gemma; Lafuente Varea, Rafael; Checa Vizcaíno, Miguel A.; Monqaut, Ana; Brassesco Macazzaga, Mario .Rev Int Androl.2011; 09 :154-9

Abstract

The appearance of new diagnostic tools in the field of andrology, have allowed the study of new sperm quality markers, such as the presence of vacuoles in the nucleus of the spermatozoa, by means of high magnification microscopy, and sperm DNA fragmentation. Both quality markers can be affected by the presence of free oxygen radicals that cause cellular oxidation. In the present pilot study we try to assess the utility of a therapy with antioxidants to significantly reduce both the sperm vacuolization grade and sperm DNA fragmentation.

Material and methods: In prospective study we included 65 patients, 33 of whom finished the study. Each patient brought two semen samples and underwent an antioxidant therapy with Androferti®. Sperm head vacuolization and DNA fragmentation were both assessed in each sample.

Results It was observed a statistically significant increase of spermatozoa from grades I and II of vacuolization after one month of treatment. Also, sperm DNA fragmentation decreased after the treatment.

Conclusions: Although this is a non-randomized study, it seems conclusive the importance of an antioxidant therapy to increase assisted reproduction outcomes, aiming to minimize the negative influence of sperm nuclear malformations and sperm DNA fragmentation.

SEE MORE

×

Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA

Abad C, Amengual MJ, Gosálvez J, Coward K, Hannaoui N, Benet J, García-Peiró A, Prats J. Andrologia. 2012 Sep 3. doi: 10.1111/and.12003

Abstract

Abstract: The primary aim of this study was to determine the effect of oral antioxidant treatment (1500 mg of l-Carnitine; 60 mg of vitamin C; 20 mg of coenzyme Q10; 10 mg of vitamin E; 10 mg of zinc; 200 μg of vitamin B9; 50 μg of selenium; 1 μg of vitamin B12) during a time period of 3 months upon the dynamics of sperm DNA fragmentation following varying periods of sperm storage (0 h, 2 h, 6 h, 8 h and 24 h) at 37 °C in a cohort of 20 infertile patients diagnosed with asthenoteratozoospermia. A secondary objective was to use the sperm chromatin dispersion test (SCD) to study antioxidant effects upon a specific subpopulation of highly DNA degraded sperm (DDS). Semen parameters and pregnancy rate (PR) were also determined. Results showed a significant improvement of DNA integrity at all incubation points (P < 0.01). The proportion of DDS was also significantly reduced (P < 0.05). Semen analysis data showed a significant increase in concentration, motility, vitality and morphology parameters. Our results suggest that antioxidant treatment improves sperm quality not only in terms of key seminal parameters and basal DNA damage, but also helps to maintain DNA integrity. Prior administration of antioxidants could therefore promote better outcomes following assisted reproductive techniques.

×

Evaluation of a antioxidant compound on seminal parameters of sperm concentration, mobility and morphology in patients with idiopatics oligoastenoteratozoospermia

Mateos Blanco, Jesús; Cabo Gonzalez, Juan Alonso Rev. Internacional Androl.2011; 09:109-15.

Abstract

Nowadays, the masculine factor is the person in charge of form isolated of 40 % of the cases of infertility of pair, sharing this protagonism of additional form in 20 % close to the feminine factor, for what of joint form, it represents 50 % of all the cases. In spite of the lack of scientific evidence, the empirical treatment has been in use widely and continues being done at present, basically to expense of compound of vitamins and other trace elements, which due to his antirust power, it would allow to improve seminal parameters as mobility or morphology.

Objetive: To study the changes in seminal parameters in a group of patients with idiophatic oligoastenoteratozoospermia, to whom they treatment was ruled by the antirust complex.

Material y métodos: 40 patients with idiophatic oligoastenoteratozoospermia were treated by the complex antirust Androferti (Laboratory Q Pharma).

Conclusions: The study demonstrated improvement of the seminal parameters concentration, progressive mobility and morphology to 3 and 6 months of treatment, presenting statistical significance the analysis of the information, which, given the improvement on the inventory of mobile sperms (REM), allows to these patients to come to technologies of assisted reproduction (TRA) as in vitro fertilization (FIV) or injection intracitoplasmática of sperms (ICSI) with major guarantee, or even, pairs who due to the initial REM necessarily had to resort to the above mentioned technology of reproduction, they can resort finally to artificial insemination (IAC) before the experienced improvement.

SEE MORE

×

Effect of the administration of an antioxidant complex in patients with idiopathic astenoteratozoospermia

Ballescá, José Luis; Oliva, Rafael; Espinosa, Nadia; Corral, Juan Manuel. Rev Int Androl.2012; 10 :51-6 - vol.10 núm 02

Abstract

Introduction: The male factor is seen in almost 50% of the couples attending a reproductive clinic, and may be a result of a decrease in sperm count (oligozoospermia) or in sperm quality due to mobility defects (asthenozoospermia) or in its morphology (teratozoospermia). There are several studies that related the these sperm quality defects with the presence of sperm DNA fragmentation and suggest the possible beneficial effect of antioxidant treatments, although there is wide disparity in the results obtained.

Objectives: We have studied the effect of the administration of an antioxidant complex (Androferti® Laboratory Q Pharma) in patients with idiopathic asthenoteratozoospermia in order to contribute to the clarification of the possible beneficial effect of the empirical administration of antioxidants, in the present work.

Patients and methods: A total of 69 males in whom the antioxidant treatment was administered at a day dose of 1.5 g for 3 months were included. After completing the treatment, significant improvement was detected in sperm mobility (global mobility a+b improved from 22.04% to 28.95%; p = 0.001) and sperm morphology (the normal forms increased from 9.86 % to 14.78%, p <0.001). Discussion: Numerous publications have reported the beneficial effects of administering antioxidant substances on sperm DNA fragmentation. These effects could be translated into an improvement in semen and embryo quality, in case of pregnancy. Our study is in line with these finding, showing an improvement in most of the seminal parameters resulting from the administration of L-carnitine in association with other antioxidants, a treatment that appears to be particularly effective in younger patients.

Conclusions: Our results confirm the beneficial effect of the administration of an antioxidant complex in patients with idiopathic asthenoteratozoospermia, this improving their sperm quality, consequently favoring the desired pregnancy.

SEE MORE

×

Effect of a treatment with vitamins, L-carnitine and coenzyme Q10 on sperm head vacuolization and DNA fragmentation on in vitro fertilization patients

López Granollers, Gemma; Lafuente Varea, Rafael; Checa Vizcaíno, Miguel A.; Monqaut, Ana; Brassesco Macazzaga, Mario .Rev Int Androl.2011; 09 :154-9

Abstract

The appearance of new diagnostic tools in the field of andrology, have allowed the study of new sperm quality markers, such as the presence of vacuoles in the nucleus of the spermatozoa, by means of high magnification microscopy, and sperm DNA fragmentation. Both quality markers can be affected by the presence of free oxygen radicals that cause cellular oxidation. In the present pilot study we try to assess the utility of a therapy with antioxidants to significantly reduce both the sperm vacuolization grade and sperm DNA fragmentation.

Material and methods: In prospective study we included 65 patients, 33 of whom finished the study. Each patient brought two semen samples and underwent an antioxidant therapy with Androferti®. Sperm head vacuolization and DNA fragmentation were both assessed in each sample.

Results It was observed a statistically significant increase of spermatozoa from grades I and II of vacuolization after one month of treatment. Also, sperm DNA fragmentation decreased after the treatment.

Conclusions: Although this is a non-randomized study, it seems conclusive the importance of an antioxidant therapy to increase assisted reproduction outcomes, aiming to minimize the negative influence of sperm nuclear malformations and sperm DNA fragmentation.

SEE MORE

×

Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA

Abad C, Amengual MJ, Gosálvez J, Coward K, Hannaoui N, Benet J, García-Peiró A, Prats J. Andrologia. 2012 Sep 3. doi: 10.1111/and.12003

Abstract

Abstract: The primary aim of this study was to determine the effect of oral antioxidant treatment (1500 mg of l-Carnitine; 60 mg of vitamin C; 20 mg of coenzyme Q10; 10 mg of vitamin E; 10 mg of zinc; 200 μg of vitamin B9; 50 μg of selenium; 1 μg of vitamin B12) during a time period of 3 months upon the dynamics of sperm DNA fragmentation following varying periods of sperm storage (0 h, 2 h, 6 h, 8 h and 24 h) at 37 °C in a cohort of 20 infertile patients diagnosed with asthenoteratozoospermia. A secondary objective was to use the sperm chromatin dispersion test (SCD) to study antioxidant effects upon a specific subpopulation of highly DNA degraded sperm (DDS). Semen parameters and pregnancy rate (PR) were also determined. Results showed a significant improvement of DNA integrity at all incubation points (P < 0.01). The proportion of DDS was also significantly reduced (P < 0.05). Semen analysis data showed a significant increase in concentration, motility, vitality and morphology parameters. Our results suggest that antioxidant treatment improves sperm quality not only in terms of key seminal parameters and basal DNA damage, but also helps to maintain DNA integrity. Prior administration of antioxidants could therefore promote better outcomes following assisted reproductive techniques.

×

Impact of an antioxidant complex supplementation on sperm DNA fragmentation in infertile men

Balmori Boticario, Carlos; Areces Viña, Cristina; Pacheco Castro, Alberto; San Celestino Carchenilla, Marta; García Velasco, Juan Antonio . Rev Int Androl.2010; 08 :107-13

Abstract

In assisted reproduction treatments it is no longer enough to obtain spermatozoa, we must find the best spermatozoa. Among the different parameters studied until recently, such as concentration, motility and morphology, varying success rates were observed even with similar classical sperm quality markers. Thus, research has been developed in order to find new markers of sperm quality. One of them is sperm DNA fragmentation. A close correlation between high sperm DNA fragmentation and poor reproductive outcome. Traditionally, and completely empirically, vitamins C and E have been used in an effort to improve sperm quality. The relationship between sperm DNA fragmentation and the excess of free radicals and/or antioxidants deficit in infertile males has raised the question whether the supplementation with antioxidant substances may improve their reproductive outcome by reducing sperm DNA fragmentation. In this study, we evaluate the impact of an antioxidant complex (Androferti®‚ Laboratorios Q Pharma) supplementation to infertile males in their sperm DNA fragmentation.

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